Monday, August 29, 2011

Menopausal Hot Flashes and CNS neurotransmition linked

Could relief be as easy as simple amino acid supplementation?

Women around the world experience vasomotor symptoms (hot flashes) as they enter and complete the menopause transition. Hot flashes, are caused by a narrowing of the thermoneutral zone in the brain. This effect, once thought strictly related to to estrogen withdrawal, is most likely related to changes in central nervous system neurotransmitters.

The latest development in management of hot flashes indicates that selective serotonin and selective nor epinephrine reuptake inhibitors and gabapentin may influence some control over hot flashes. While estrogen replacement therapy has long been the protocol used to treat menopausal hot flashes this new research suggests to me that their may be a role for amino acid supplementation therapy to help reduce hot flashes! I am currently testing this on myself by using 5-HTP, and GABA before bedtime. The report states that - "Of the other interventions investigated, selective serotonin and selective norepinephrine reuptake inhibitors and gabapentin show efficacy greater than placebo. Objective monitoring of hot flushes indicates a robust improvement with hormone replacement therapy but little to no change with placebo"

Additionally, based on preliminary reports, women experiencing hot flashes have an increased risk of cardiovascular disease and a reduced incidence of breast cancer.

You can read the abstract here:
http://www.ncbi.nlm.nih.gov/pubmed/21848495?dopt=Abstract

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